Q: Which 2 group of drugs may increase the chances of Hypersensitive reactions (HSRs) to intravenous Iron infusion?

 

Answer: Beta blockers and ACE inhibitors

Few risk factors associated with high risk of HSRs to IV Fe infusion are previous reaction to IV Fe, fast infusion, history of various allergies, history of asthma, eczema or systemic inflammatory disease, concomitant use of beta blocker or ACE inhibitor, old age, or anxiety either on patient or staff part.

IV Fe infusion should not be given in first trimester of pregnancy and should be given with caution in severe underlying respiratory or cardiac illness.