On Post cardiac surgery vasodilatation (PCSV)

Post cardiac surgery vasodilatation (PCSV) is possibly related to a vasopressin deficiency that could relate to chronic stimulation of adeno-hypophysis. It is shown that patients who experienced PCSV had significantly

•  higher copeptin plasma concentration before cardiopulmonary bypass
• lower arginine vasopressin (AVP) concentrations at 8th postoperative hour (H8)

PCSV patients had

• preoperative hyponatremia
• decreased left ventricle ejection fraction, and
• experienced more complex surgery (alike redo)

The best predictive value for preoperative copeptin plasma concentration was 9.43 pmol/l with a sensitivity of 90% and a specificity of 77%.




Reference:

Pascal H Colson, Cedric Bernard, Joachim Struck, Nils G Morgenthaler, Bernard Albat and Gilles Guillon - Post cardiac surgery vasoplegia is associated with high preoperative copeptin plasma concentration - Critical Care 2011, 15:R255