Sunday, June 14, 2015

Q: Which antibiotic can be used to counter cholestatic pruritus?

Answer: Rifampicin

Rifampicin can be used in the treatment of cholestatic pruritus. Actual mechanism of action is not very clear though.  First line therapy is generally cholestyramine, a bile acid sequestrant. But if needed Rifampicin can be used for patient's comfort.


Hofmann, AF (2002). "Rifampicin and treatment of cholestatic pruritus". Gut 2002;50:436–9 51 (5): 756–757.

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