Q: Which antibiotic can be used to counter cholestatic pruritus?
Rifampicin can be used in the treatment of cholestatic pruritus. Actual mechanism of action is not very clear though. First line therapy is generally cholestyramine, a bile acid sequestrant. But if needed Rifampicin can be used for patient's comfort.
Hofmann, AF (2002). "Rifampicin and treatment of cholestatic pruritus". Gut 2002;50:436–9 51 (5): 756–757.