Monday, June 15, 2015

Q: One of the advantage dronedarone (Multaq) has over amiodarone, is reduced toxicity due to absence of  the iodine moieties, which reduces iodine based toxicity paricularly in lungs and thyroid. What other advantage dronedarone has over Amiodarone?

Answer: Dronedarone is a benzofuran derivative related to amiodarone. Amiodarone though very popular but is well known for its toxicity due its high iodine content. In dronedarone, the iodine moieties are not present, reducing toxic effects. Another advantage, Dronedarone has a  methylsulfonamide group is added to reduce its lipophilicity,  and thus also reduces neurotoxic effects. 


Zimetbaum, PJ (2009). "Dronedarone for atrial fibrillation--an odyssey". The New England Journal of Medicine 360 (18): 1811–3.

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