Wednesday, July 1, 2015

Q: Which of the following antihypertensive may be use in treatment of myelodysplastic syndrome (MDS)?

A) Lopressor
B) Clonidine
C) Lisinopril
D) Hydralazine
E) Methyldopa 

Answer:  D 

Hydralazine has also been used successfully as a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase inhibitor along with magnesium valproate.


Candelaria, M; Herrera, A; Labardini, J; González-Fierro, A; Trejo-Becerril, C; Taja-Chayeb, L; Pérez-Cárdenas, E; Cruz-Hernández, E; Arias-Bofill, D; Vidal, S; Cervera, E; Dueñas-Gonzalez, A (5 October 2010). "Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome. Preliminary results of a phase-II trial". Annals of Hematology 90 (4): 379–387

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