Thursday, June 30, 2016

Q: Linezolid causes lactic acidosis due to mitochondrial dysfunction. It requires at least 2 weeks of intake/infusion?  - True or False?

Answer: False

Previously it was thought that  linezolid driven lactic acidosis requires prolonged course of antibiotic treatment, but now reports suggest it can occur even at initiation of the antibiotic, particularly if patient may have underlying MELAS syndrome (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes).

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