Tuesday, September 27, 2016

Q: Why endomyocardial biopsy has high false negative results in cardiac sarcoidosis?

Answer: Endomyocardial biopsy in cardiac sarcoidosis has a very high rate of false negative results due to two reasons. First, the disease has a patchy distribution. And second, myocardial granulomas usually affects the basal and lateral left ventricular (LV) wall regions which are difficult to reach for biopsy.


Uemura A, Morimoto S, Hiramitsu S, et al. Histologic diagnostic rate of cardiac sarcoidosis: evaluation of endomyocardial biopsies. Am Heart J 1999; 138:299.

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