Q: What is the appropriate dose of oral vancomycin in C.diff. associated diarrhea (CDAD)?
Answer: 125 mg four times daily
Though popular dose is 500 mg four times daily, but studies fail to show any superiority of higher dose.
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2. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010; 31:431.