Monday, September 26, 2016

Q: What is the appropriate dose of oral vancomycin in C.diff. associated diarrhea  (CDAD)?

Answer:  125 mg four times daily

Though popular dose is 500 mg four times daily, but studies fail to show any superiority of higher dose.


1. Fekety R, Silva J, Kauffman C, et al. Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimens. Am J Med 1989; 86:15. 

2. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010; 31:431.

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