Q: What is Solvent/Detergent-Treated Plasma (SD Plasma)? 

 Answer: Fresh frozen plasma (FFP) despite all precautions still carry minor risk of viral transmission. The solvent/detergent (SD) is a special process by which plasma get safely inactivated all lipid-enveloped viruses. 

Clinical significance: SD plasma found to have lesser incidence of TRALI (Transfusion Related Acute Lung Injury) over FFP, as well as lower incidence of allergic reactions. It has been increasingly used in liver transplant cases.


References:

1.  Krusius T, Auvinen M-K, Tuimala Introduction of Octaplas® in clinical use decreased the rate of serious adverse reactions. Vox Sang. 2010;99(suppl 1):P-1018. 

2. Solheim BG, Bergan A, Brosstad F, Innes R, Svennevig JL. Fibrinolysis during liver transplant is enhanced by using solvent/detergent virus inactivated plasma (ESDEP/Ocatplas®) (Letter) Anesth Analg. 2003;96:1230–1231. 

3. Peter Hellsterna, and Bjarte G. Solheimb - The Use of Solvent/Detergent Treatment in Pathogen Reduction of Plasma - Transfus Med Hemother. 2011 Feb; 38(1): 65–70. Published online 2011 Jan 17.

4. Horowitz B1, Bonomo R, Prince AM, Chin SN, Brotman B, Shulman RW. - Solvent/detergent-treated plasma: a virus-inactivated substitute for fresh frozen plasma. - Blood. 1992 Feb 1;79(3):826-31.