Q: Lactic acidosis due to Linezolid requires at least two weeks of administration?

A) True
B) False


Answer:  B

Linezolid acts at bacterial ribosomes but can also affect human mitochondrial ribosomes and may lead to lactic acidosis. Usually linezolid-induced lactic acidosis happens after few days of therapy but now case reports have been out of lactic acidosis at induction of therapy.



References:

Velez JC, Janech MG. A case of lactic acidosis induced by linezolid. Nat Rev Nephrol 2010; 6:236.