Q: Though administration of foscarnet can cause various electrolyte dysfunctions, which electrolyte abnormality is established and need attention?



Answer: Foscarnet is used for the treatment of ganciclovir-resistant cytomegalovirus (CMV). It is establish to cause hypocalcemia via forming complex formation with free calcium. Attention should also be paid if simultaneous hypomagnesemia is present. Without treating magnesium depletion, hypocalcemia will not get better.


Reference:

Guillaume MP, Karmali R, Bergmann P, Cogan E. Unusual prolonged hypocalcemia due to foscarnet in a patient with AIDS. Clin Infect Dis 1997; 25:932.