Q: Among the second-generation antipsychotics (SGAs) (atypical antipsychotics), which of the following has the highest risk of Extrapyramidal side effects (EPS)?
A) risperidone
B) aripiprazole
C) asenapine
D) quetiapine
E) clozapine
Answer: A
Out of all the SGAs, risperidone carries the highest risk of EPS. Ideally, it should not be used beyond 4 mg/day. Aripiprazole, asenapine, cariprazine, lurasidone, and paliperidone also carries some risk for EPS but less than risperidone.
Quetiapine and clozapine are considered the safest.
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#psychiatry
#pharmacology
References:
1. Marder SR, Meibach RC. Risperidone in the treatment of schizophrenia. Am J Psychiatry 1994; 151:825.
2. Peuskens J. Risperidone in the treatment of patients with chronic schizophrenia: a multi-national, multi-centre, double-blind, parallel-group study versus haloperidol. Risperidone Study Group. Br J Psychiatry 1995; 166:712.
3. Seppi K, Weintraub D, Coelho M, et al. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease. Mov Disord 2011; 26 Suppl 3:S42.
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