Wednesday, January 23, 2019

Calcium channel blockers and dialysis

Q: Calcium channel blockers (CCBs) get removed by hemodialysis (HD)? (select one)

A) Yes
B) No


Answer: B

As CCBs are highly protein bound, they can not be removed by hemodialysis.

This small piece of information is very vital in toxicology to learn that  HD has no role in CCBs overdose.


#toxicology
#pharmacology
#nephrology



Reference: 

Sica DA, Gehr TW. Calcium-channel blockers and end-stage renal disease: pharmacokinetic and pharmacodynamic considerations. Curr Opin Nephrol Hypertens. 2003 Mar;12(2):123-31.

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