Q: What is I-FABP in intestinal ischemia?
Answer: I-FABP is an intestinal fatty acid-binding protein and is a good marker of intestinal ischemia. I-FABP is a water-soluble protein abundantly present in the mucosa of the small bowel from the duodenum to the ileum. It rapidly starts releasing into the bloodstream whenever there is a small intestinal mucosal damage due to ischemia.
1. Kanda T, Fujii H, Tani T, et al. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans. Gastroenterology 1996; 110:339.
2. Matsumoto S, Sekine K, Funaoka H, et al. Diagnostic performance of plasma biomarkers in patients with acute intestinal ischaemia. Br J Surg 2014; 101:232.