Wednesday, March 20, 2019

solitary hypoalbuminemia and non-cardiogenic edema

Q: Solitary hypoalbuminemia can cause non-cardiogenic edema? 

A) True
B) False

Answer: B

It is true that pure hypoalbuminemia causes the peripheral edema due to the lowering of the transcapillary oncotic pressure gradient, but pulmonary capillaries have a greater baseline permeability to albumin. Because of this high permeability, a fall in the plasma albumin concentration is accompanied by a parallel decline in the pulmonary interstitial oncotic pressure, and the net effect is little or no change in the transcapillary oncotic pressure gradient.




Taylor AE. Capillary fluid filtration. Starling forces and lymph flow. Circ Res 1981; 49:557.

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