Sunday, March 3, 2019

Diuretic as anti-seizure

Q: Which diuretic has shown some promise in suppressing temporal lobe epilepsy?

Answer:  Bumetanide 

Bumetanide has been used in neonatal refractory seizures with success. It is an inhibitor of Na-K-Cl cotransporter (NKCC). The human body has Two isoforms of NKCC

  • NKCC1 is expressed in the brain, and 
  • NKCC2 is expressed in the kidney 

It has shown the potential of use in patients with temporal lobe epilepsy. 



1. S. Eftekhari, J. Mehvari Habibabadi, M. Najafi Ziarani, et al. Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy Epilepsia, 54 (2013), pp. e9-12

2. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model Ann Neurol, 63 (2008), pp. 222-235 

3.  K.T. Kahle, K.J. Staley The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures Neurosurg Focus, 25 (2008), Article E22

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