HBV in pregnancy

Q: Acute Hepatitis B Virus (HBV) has the highest rate of transmission? (select one)

A) early in the pregnancy
B) near the time of delivery


Answer: B

This piece of maternal hepatology is extremely important to know as an active intervention is required if HBV occurs near the time of delivery.

Transmission to the fetus may be as low as 10 percent in the early part of the pregnancy but may go up to 60 percent at the time of delivery. Hepatitis panel should be followed closely. If hepatitis B surface antigen (HBsAg) stays positive or has detectable serum HBV DNA near the delivery, baby should receive hepatitis B immune globulin and the 1st dose of the hepatitis B vaccine within 12 hours of birth. Ideally, a hepatologist should be consulted.

#hepatology
#OB-Gyn


References:

1. Sookoian S. Liver disease during pregnancy: acute viral hepatitis. Ann Hepatol 2006; 5:231. 

 2. Jonas MM. Hepatitis B and pregnancy: an underestimated issue. Liver Int 2009; 29 Suppl 1:133.