Rapid acting insulin in DKA

Q: Use of rapid-acting insulin analog instead of regular insulin improves outcome in Diabetic Ketoacidosis (DKA)? (select one)

A) True
B) False


Answer: B

Rapid-acting insulins which include Aspart, Glulisine and Lyspro is used in insulin pumps as continuous subcutaneous insulin infusion. It was proposed that they may improve outcome in DKA if used intravenously instead of regular insulin, but clinical studies failed to show any benefit.

#endocrinology


Reference:

Umpierrez GE, Jones S, Smiley D, et al. Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial. Diabetes Care 2009; 32:1164.