Q: What added advantage phenobarbital has in the treatment of theophylline-induced seizures?
Answer: Barbiturates is the drug of choice in theophylline toxicity. But in case, phenobarbital is used to treat theophylline-induced seizure - it has the added advantage of enhancing the hepatic metabolism of theophylline.
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Reference:
Landay RA, Gonzalez MA, Taylor JC.
Effect of phenobarbital on theophylline disposition.
J Allergy Clin Immunol. 1978 Jul;62(1):27-9.
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