Friday, August 2, 2019

Ibutalide and TdeP

Q: All of the following are the risk factors for torsade de pointes (TdeP) after ibutilide administration except?  

A) Congestive heart failure 
B) Baseline increase QTc interval 
C) Hypokalemia 
D) Hypomagnesemia 
E) Associated atrial flutter




Answer: E

Ibutilide is found to be more effective in converting atrial flutter to sinus rhythm. All other are risk factors for TdeP while administrating Ibutilide. This risk can be minimized by administrating extra magnesium prior to ibutilide. It is recommended to watch closely and at least for four hours, for prolong QTc interval after Ibutilide is given.


#cardiology

#pharmacology



References:

1. Ellenbogen KA, Stambler BS, Wood MA, et al. Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose-response study. J Am Coll Cardiol 1996; 28:130. 


2. Patsilinakos S, Christou A, Kafkas N, et al. Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent. Am J Cardiol 2010; 106:673.

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