TLS

Q: All of the following electrolyte/lab abnormalities are part of Cairo-Bishop definition of laboratory tumor lysis syndrome except? 

A) Uric acid
B) Potassium 
C) Phosphorus
D) Calcium
E) Sodium


Answer: E 

Cairo-Bishop laboratory definition is the easiest way to establish the diagnosis of tumor lysis syndrome. If two or more laboratory values of uric acid, potassium, phosphorus, and calcium change > 25% at presentation or seven days after cytotoxic therapy.

#hematology


References: 

1. Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol 2004; 127:3. 

2. Coiffier B, Altman A, Pui CH, et al. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol 2008; 26:2767