anticoagulation in APS

Q: In patients with antiphospholipid syndrome (APS) who require anticoagulation, which of the following is preferred drug? 


A) warfarin 
B) rivaroxaban 
C) dabigatran 
D) apixaban 
E) edoxaban


Answer: A

Direct oral anticoagulants (DOACs) are fastly getting popular but there are few instances where either warfarin or heparin is still preferred. These include prosthetic heart valves, pregnancy, renal impairment, severe liver disease and antiphospholipid syndrome. 

In antiphospholipid syndrome (APS), warfarin is still a preferred anticoagulation as there is no substantial supportive data available in the favor of DOACs.

#pharmacology
#rheumatology 


Reference:

Garcia D, Erkan D. Diagnosis and Management of the Antiphospholipid Syndrome. N Engl J Med 2018; 378:2010-2021