Sunday, October 6, 2019

Hy's law

Q: What is "Hy's law" of Drug-Induced-Liver-Injury (DILI)?

 Answer: "Hy's law" is named after Dr. Hyman Zimmerman who proposed that 'if serum bilirubin is > 2 times the upper limit of normal in association with > 3 times elevation in serum aminotransferases, it predicts worse prognosis in DILI.'




1. Reuben A. Hy's law. Hepatology 2004; 39:574.

2. Bj√∂rnsson E. Drug-induced liver injury: Hy's rule revisited. Clin Pharmacol Ther 2006; 79:521. 

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