plasma fibrinogen levels

Q: All of the following increase circulating plasma fibrinogen levels except? 

A) age
B) obesity
C) smoking
D) inflammation
E) alcoholism


Answer: E

Fibrinogen is an essential polypeptide in clot formation. It works via various mechanisms. It is the precursor to fibrin. It not only binds platelets but also supports platelet and thrombin aggregations. The most important thing is to be always mindful of the "fine balance" between fibrin clot formation and fibrinolysis. All other choices besides alcohol consumption increase the risk of clot formation and so of deep venous thrombosis (DVT).

#hematology


Reference:

Meade TW, Chakrabarti R, Haines AP, et al. Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. Br Med J 1979; 1:153.