Q: Diabetes ____________ the risk for Abdominal Aortic Aneurysms (AAA)? (select one)
A) increases
B) decreases
Answer: B
Although diabetes is well known to increase the risk for any vascular disease but surprisingly it decreases the risk for AAA. The most popular hypothesis regarding this protection is mediated through effects on aortic mural neoangiogenesis, intraluminal thrombus formation, inflammation, glycation, extracellular matrix remodelling, and vascular smooth muscle homeostasis. Similar effect has been reported for Thoracic-AA but pathways may be different.
#surgical-critical-care
Reference:
Juliette Raffort, Fabien Lareyre, Marc Clément, Réda Hassen-Khodja, Giulia Chinetti, Ziad Mallat.
Diabetes and aortic aneurysm: current state of the art
Cardiovascular Research, Volume 114, Issue 13, 01 November 2018, Pages 1702–1713, https://doi.org/10.1093/cvr/cvy174
No comments:
Post a Comment