Tuesday, December 31, 2019

octreotide in chylothorax

Q: How octreotide helps in chylothorax? 


Octreotide can be an important adjunct therapy in chylothorax. It works via two mechanisms 

  •  decrease the volume of fluid within the thoracic duct by inhibiting gastric, pancreatic, and biliary secretions, and 
  •  inhibiting absorption of chyle from the intestine
One dose regimen is 50 to 100 mcg SQ 3/day.



1. Kalomenidis I. Octreotide and chylothorax. Curr Opin Pulm Med 2006; 12:264.

2.  Al-Zubairy SA, Al-Jazairi AS. Octreotide as a therapeutic option for management of chylothorax. Ann Pharmacother 2003; 37:679. 

3. Evans J, Clark MF, Mincher L, Varney VA. Chylous effusions complicating lymphoma: a serious event with octreotide as a treatment option. Hematol Oncol 2003; 21:77.

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