Q: Which form of potassium administration gives the fastest potassium repletion?
A) Potassium phosphate
B) Potassium chloride
C) Potassium bicarbonate
Out of all three preparations of potassium repletion, potassium chloride raises serum potassium concentration fastest. This is due to the fact that chloride is primarily an extracellular anion and only partially crosses the cell membrane. This is also advantageous in patients who develop hypokalemia from either diuretic therapy or vomiting, and are also chloride deficient.
The administration of non-chloride potassium salts provides only 40% of the administrated potassium.
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