Q; 32 year old female is admitted to ICU due to hypovolemic shock after having a severe uterine bleed. OB-Gyn service has been called to assist in management. Besides other standard treatment Nonsteroidal anti-inflammatory drug (NSAIDs) has been prescribed as an adjuvant treatment. How the NSAIDS directly help in abnormal uterine bleed (AUB)?
Answer: NSAIDs decrease the volume of menstrual blood by causing a decline in the rate of prostaglandin synthesis in the endometrium, leading to vasoconstriction and consequently reduced bleeding. Mostly prescribed NSAIDs are Mefenamic acid, Naproxen, and Ibuprofen.
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