Friday, January 3, 2020


Q; 32 year old female is admitted to ICU due to hypovolemic shock after having a severe uterine bleed. OB-Gyn service has been called to assist in management. Besides other standard treatment Nonsteroidal anti-inflammatory drug (NSAIDs) has been prescribed as an adjuvant treatment. How the NSAIDS directly help in abnormal uterine bleed (AUB)?

Answer:  NSAIDs decrease the volume of menstrual blood by causing a decline in the rate of prostaglandin synthesis in the endometrium, leading to vasoconstriction and consequently reduced bleeding. Mostly prescribed NSAIDs are Mefenamic acid, Naproxen, and Ibuprofen.



1. Rees MC, DiMarzo V, Tippins JR, et al. Leukotriene release by endometrium and myometrium throughout the menstrual cycle in dysmenorrhoea and menorrhagia. J Endocrinol 1987; 113:291. 

2. Smith SK, Abel MH, Kelly RW, Baird DT. Prostaglandin synthesis in the endometrium of women with ovular dysfunctional uterine bleeding. Br J Obstet Gynaecol 1981; 88:434.

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