Saturday, January 4, 2020


Q: Modafinil is indicated for shift workers like ICU nurses, intensivists or ED nurses/physicians? (select one)

A) One hour before shift
B) One hour after shift

Answer: A

Modafinil binds to the dopamine transporter and inhibits dopamine reuptake, and increases dopamine levels in different parts of the brain. Said that this mechanism of action is demonstrated in the animal models. Its primary mechanism of action remains elusive.

The prescription should be obtained after thorough workup and under the supervision of an experienced/trained physician. 



1. Gerrard P, Malcolm R. Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat. 2007;3(3):349–364.

2.  Alertec (modafinil) [product monograph]. Toronto, Ontario, Canada: Teva Canada Limited; June 2019.

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