Sunday, April 26, 2020

Dexmedetomidine Clonidine

Q: Infusion of dexmedetomidine in ICU patients can be transitioned to which oral medicine? 

Answer: Clonidine

Although not routinely utilized but dexmedetomidine can be transitioned to oral clonidine. It is safe as well as cost-effective. This is due to the fact of their similar mechanism of action via centrally acting alpha-2-agonist effect. Dexmedetomidine can be gradually titrated down with escalation of clonidine dosage up to 0.2 to 0.5 mg every six hours.



Gagnon DJ, Riker RR, Glisic EK, et al. Transition from dexmedetomidine to enteral clonidine for ICU sedation: an observational pilot study. Pharmacotherapy 2015; 35:251.

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