Q: According to famous PROSEVA (Prone Positioning in Severe Acute Respiratory Distress Syndrome) trial, early proning is recommended. What was the cutoff time used in trial?
Answer: 33 hours
PROSEVA trial despite its various limitations is considered a landmark work in ARDS. It showed that prone positioning can be beneficial to patients with severe ARDS who are on mechanical ventilator, and already getting treated with low tidal volume protocol. Benefit of proning is best achieved if done within 33 hours of intubation, and be done for at least 16-18 hours per day. It showed overall reduction in 28-days mortality between intervention and controlled arm (16 versus 32.8 percent).
#pulmonary
Reference:
Guérin C, Reignier J, Richard JC, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013; 368:2159.
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