Q: 23-year-old female with past medical history of Multiple Sclerosis (MS) is admitted to ICU with severe optic neuritis. Which one test may predict between favorable or unfavorable outcome?
Answer: aquaporin-4-specific serum antibodies
In general, African-Americans and patients with MS have less favorable prognosis in optic neuritis. In patients with MS prognosis can be predicted by measuring aquaporin-4-specific serum antibodies. Patients with aquaporin-4-specific serum antibodies may have poorer visual outcomes.
#neurology
References:
1. Martinez-Hernandez E, Sepulveda M, Rostásy K, et al. Antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and the glycine receptor α1 subunit in patients with isolated optic neuritis. JAMA Neurol 2015; 72:187.
2. Kimbrough DJ, Sotirchos ES, Wilson JA, et al. Retinal damage and vision loss in African American multiple sclerosis patients. Ann Neurol 2015; 77:228.
3. Moss HE, Gao W, Balcer LJ, Joslin CE. Association of race/ethnicity with visual outcomes following acute optic neuritis: an analysis of the Optic Neuritis Treatment Trial. JAMA Ophthalmol 2014; 132:421.
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