Saturday, August 22, 2020

Meperidine

Q: Meperidine can have which effect? (select one) 

A) Dysphoria 
B) Euphoria


Answer:

Physicians may get into the cognitive bias that the patients who are requesting meperidine are looking for euphoria. On the contrary, meperidine can cause distressing dysphoria. In ICU it should be used with caution as due to its well-known toxic metabolite normeperidine, which has serotonergic properties, and drug-drug interaction it has a high risk of causing serotonin syndrome and seizure.

#pharmacology


References:

1. Latta KS, Ginsberg B, Barkin RL. Meperidine: a critical review. Am J Ther 2002; 9:53.

2. Yasaei R, Rosani A, Saadabadi A. Meperidine. [Updated 2020 May 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470362/

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