Saturday, March 20, 2021

Post-transplant diabetes

 Q: The newly transplanted kidney excretes insulin more efficiently than previously failed native kidneys? 

A) True 

B) False 

 Answer: A

There is more than one reason for new-onset diabetes mellitus after transplantation (NODAT) particularly after kidney transplant. Blood glucose monitoring continued to be essential monitoring in newly transplanted patients. The new kidney metabolizes and excretes insulin more efficiently. Also, the new kidney is gluconeogenic. These extra myriads are in conjunction with the inherent risks of immunosuppressants required in most post-transplant patients. Post-transplant issues such as age, obesity, and gestations further compound the issue of NODAT.




1. Shivaswamy V, Boerner B, Larsen J. Post-Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes. Endocr Rev. 2016;37(1):37-61. doi:10.1210/er.2015-1084 

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