Saturday, July 31, 2021

CF and Na

 Q; 24 years old male with a history of Cystic Fibrosis (CF) is admitted to ICU with severe dehydration after a long day outdoors in the summer. All of the following abnormalities are expected EXCEPT?

A) hypernatremia 

B) hypochloremia 

C) hypokalemia 

D) metabolic alkalosis


Answer: A 

Though unusual, electrolyte abnormalities can be presenting symptoms in patients with CF. This is popularly known as pseudo-Bartter syndrome. This condition occurs due to excessive loss of NaCl during sweating, compounded by decrease sodium intake.

#electrolyte imbalance


References:

1. Vilotijević-Dautović G, Stojanović V. Pseudo-Bartter's Syndrome in Patients with Cystic Fibrosis: A Case Series and Review of the Literature. Srp Arh Celok Lek. 2015 Nov-Dec;143(11-12):748-51. doi: 10.2298/sarh1512748v. PMID: 26946774. 

2. Scurati-Manzoni E, Fossali EF, Agostoni C, et al. Electrolyte abnormalities in cystic fibrosis: systematic review of the literature. Pediatr Nephrol 2014; 29:1015. 

3. Ghimire S, Yerneni H, Oyadomari TA, Sedlacek M. Metabolic Alkalosis and Cystic Fibrosis: A Case Report. Ann Intern Med 2020; 173:315. 

4. Dahabreh MM, Najada AS. Pseudo-bartter syndrome, pattern and correlation with other cystic fibrosis features. Saudi J Kidney Dis Transpl. 2013 Mar;24(2):292-6. doi: 10.4103/1319-2442.109579. PMID: 23538352.

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