Desmopressin oral to IV

Q: What's the ratio of Desmopressin for oral to intravenous (IV) form?

Answer: 400:1

Desmopressin has a wide variety of dose bioavailability depending on the route. Four major routes available are melt (sublingual), tablet, spray, and IV. Doses have different dose comparability.

Melt:Tablet:Spry:IV 

= 240:400:10:1*

- All doses in mcg

* It's even less than 1 mcg

Moreover, bioavailability varies between manufacturers, regions, and countries. To make things more confusing, not all formulations are approved for any given disease process.

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Reference;

Oiso Y, Robertson GL, Nørgaard JP, Juul KV. Clinical review: Treatment of neurohypophyseal diabetes insipidus. J Clin Endocrinol Metab 2013; 98:3958-67. https://www.endocrine.org/journals/jcem. Copyright © 2013 The Endocrine Society.