Q: Tramadol _________________ the reuptake of serotonin? (select one)
A) blocks
B) Exacerbates
Answer: Although Tramadol is an opioid agonist, it is popular in postop care due to its characteristic of lesser frequency of constipation and dependency/addiction. It works via blocking reuptake of serotonin and norepinephrine.
Clinical significance: Its mechanism of action increases the risk of serotonin syndrome, particularly when other serotonergic agents are on board.
#pharmacology
#neurology
Reference:
Beakley BD, Kaye AM, Kaye AD. Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review. Pain Physician. 2015 Jul-Aug;18(4):395-400. PMID: 26218943.
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