first-line therapy for status epilepticus

Q: Which of the following is considered first-line therapy for status epilepticus? (select one)

A) Clonazepam 

B) Lorazepam

C) Both clonazepam and lorazepam

Answer: C

Clonazepam is as good as lorazepam as first-line therapy for status epilepticus. In fact, there is weak evidence that clonazepam may be slightly superior. Unfortunately, Intravenous (IV) clonazepam is unavailable in the USA.

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References: 

1. Alvarez V, Lee JW, Drislane FW, et al. Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparison. Epilepsia 2015; 56:1275.

2. Shorvon S, Baulac M, Cross H, et al. The drug treatment of status epilepticus in Europe: consensus document from a workshop at the first London Colloquium on Status Epilepticus. Epilepsia 2008; 49:1277.