ACS in SCD

Q: What is the diagnostic criteria of Acute Chest Syndrome (ACS) in Sickle cell disease?

Answer: ACS is defined by a new pulmonary density on chest imaging involving at least one complete lung segment or diagnosis of Pneumonia, and at least one of the following:

• Temperature ≥38.5°C
• >3 percent decrease in SpO2 (oxygen saturation) from a documented steady-state value on room air
• Tachypnea (per age-adjusted normal)
• Intercostal retractions, nasal flaring, or use of accessory muscles of respiration
• Chest pain
• Cough
• Wheezing
• Rales

#hematology

#pulmonary

Reference:

Ballas SK, Lieff S, Benjamin LJ, et al. Definitions of the phenotypic manifestations of sickle cell disease. Am J Hematol 2010; 85:6.