Q: 32 years old male was discharged four weeks ago from the hospital when he was admitted due to severe schizophrenia. He now presented to the emergency department with shortness of breath and was found to be in acute congestive heart failure. Which of the following drug is the probable culprit? (select one)
A) Risperidone
B) Quetiapine
C) Olanzapine
D) Ripiprazole
E) Clozapine
Answer: E
Although rare, clozapine-induced myocarditis can cause cardiomyopathy, and all patients should be watched closely in the first month of prescription for congestive heart failure (CHF) symptoms. Ideally, all patients should be ruled out for any underlying cardiac pathology before starting clozapine.
As expected, treatment is the discontinuation of medicine and supportive treatment. Fortunately, with discontinuation of clozapine, cardiomyopathy usually resolves.
#cardiology
#pharmacology
#psychiatry
References:
1. Haas SJ, Hill R, Krum H, et al. Clozapine-associated myocarditis: a review of 116 cases of suspected myocarditis associated with the use of clozapine in Australia during 1993-2003. Drug Saf 2007; 30:47.
2. http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019758s080lbl.pdf (Accessed on August 17, 2023).
No comments:
Post a Comment