V710

Q: 52 years old basic sciences professor is admitted a night prior to ICU for an elective coronary artery bypass grafting (CABG) in the morning. Being a scientific person, he preferred to use Staphylococcus aureus vaccine (V710) instead of perioperative antibiotics. He heard about this vaccine a few years ago in a conference and was impressed. V710 vaccine is an approach in perioperative antimicrobials, and though not covered by insurance, has shown to improve outcomes in CABG surgeries.

A) True

B) False

Answer: B

S. aureus vaccine, also known as V710 remained investigational since last decade, and is not approved for clinical practice. Moreover, the independent data monitoring committee at Duke University Medical Center recommended termination of the study after the second interim analysis because of safety concerns, low efficacy, and chances of increased mortality.

#cardiac-surgery

#ID

Reference:

Fowler VG, Allen KB, Moreira ED, Moustafa M, Isgro F, Boucher HW, Corey GR, Carmeli Y, Betts R, Hartzel JS, Chan IS, McNeely TB, Kartsonis NA, Guris D, Onorato MT, Smugar SS, DiNubile MJ, Sobanjo-ter Meulen A. Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial. JAMA. 2013 Apr 3;309(13):1368-78. doi: 10.1001/jama.2013.3010. PMID: 23549582.