Pregnancy and PICC

Q: 28 years old female required to have peripherally inserted central catheter (PICC) for long-term antibiotics. Pregnancy increases the risk of deep venous thrombosis (DVT).

A) True

B) False

  

Answer: A

Any physiologic, unphysiological, or iatrogenic hormonal change in the body may increase the risk of DVT, including pregnancy. This also includes non-catheter-related upper extremity DVΤ. 

A similar risk exists for oral contraceptives, particularly in patients with prothrombotic mutations, such as prothrombin 20210 or factor V Leiden. This risk remains relatively high in patients undergoing ovulation induction and in vitro fertilization.

#ob-gyn

#hematology

References:

1. Jacques L, Foeller M, Farez R, et al. Safety of peripherally inserted central catheters during pregnancy: a retrospective study. J Matern Fetal Neonatal Med 2018; 31:1166.

2. Vayá A, Mira Y, Mateo J, et al. Prothrombin G20210A mutation and oral contraceptive use increase upper-extremity deep vein thrombotic risk. Thromb Haemost 2003; 89:452.

3. Loret de Mola JR, Kiwi R, Austin C, Goldfarb JM. Subclavian deep vein thrombosis associated with the use of recombinant follicle-stimulating hormone (Gonal-F) complicating mild ovarian hyperstimulation syndrome. Fertil Steril 2000; 73:1253.

4. Rao AK, Chitkara U, Milki AA. Subclavian vein thrombosis following IVF and ovarian hyperstimulation: a case report. Hum Reprod 2005; 20:3307.