Anbx and SA

Q: Which antibiotic is known to cause sideroblastic aոemiа (SA)? - select one

A) Amoxicillin

B) Azithromycin

C) Ciprofloxacin

D) Doxycycline

E) Linezolid 

Answer: E

The three most common antibiotics to cause drug-induced sideroblastic аոemiа are,.

1. Isoniazid 
2. Chloramphenicol 
3. Linezolid 

Other non-antibiotic drugs which have been reported in the literature are:

• Busulfan
• Cycloserine
• Dolutegravir
• Fusidic acid
• Levodopa/Carbidopa
• Melphalan
• Penicillamine
• Pristinamycin
• Pyrazinamide

#hematology

#pharmacology

#ID

References:

1. Montpetit MC, Shammo JL, Loew J, et al. Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device. J Heart Lung Transplant 2004; 23:1119.

2. Saini N, Jacobson JO, Jha S, et al. The perils of not digging deep enough--uncovering a rare cause of acquired anemia. Am J Hematol 2012; 87:413.

3. Liapis K, Vrachiolias G, Spanoudakis E, Kotsianidis I. Vacuolation of early erythroblasts with ring sideroblasts: a clue to the diagnosis of linezolid toxicity. Br J Haematol 2020; 190:809.