Q: Give at least three reasons why Low molecular weight heparin (LMWH) is generally preferred over UnFrationated Heparin (UFH) during pregnancy?
Answer: Low molecular weight heparin (LMWH) is generally preferred over UFH during pregnancy for multiple reasons like:
- lower risk of HIT
- lower impact on osteoporosis
- can be easily self-administrated
- more bioavailability
- longer half-life
Also, to remember: During pregnancy, blood volume increases and renal function changes, which can affect how anticoagulants work. Dosing adjustments are important to maintain therapeutic levels while minimizing the risk of bleeding.
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References:
1. Casele HL. The use of unfractionated heparin and low molecular weight heparins in pregnancy. Clin Obstet Gynecol. 2006 Dec;49(4):895-905. doi: 10.1097/01.grf.0000211958.45874.63. PMID: 17082684.
2. Fouda UM, Sayed AM, Abdou AM, Ramadan DI, Fouda IM, Zaki MM. Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome. Int J Gynaecol Obstet. 2011 Mar;112(3):211-5. doi: 10.1016/j.ijgo.2010.09.010. Epub 2011 Jan 19. PMID: 21251653.
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