Q: Patients with acute exacerbation of chronic pain can tolerate higher than recommended dose acetaminophen and should be tried on it before administrating other classes of analgesia.
A) True
B) False
Answer: B
The recommended maximum dose of аϲеtаmiոοpheո is 4 grams per day. This recommendation is for naive pain patients. Long-term users of acetaminophen should not be given more than 3 grams per day. They may have some underlying subclinical hepatic disease. This dose should even be lowered in the elderly and patients with hepatic disease.
Although not very much appreciated, patients who take acetaminophen on a chronic basis are also more prone to develop renal insufficiency, hypertension, chronic headache, and peptic ulcer disease.
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#pharmacology
References:
1. Bolesta S, Haber SL. Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors. Ann Pharmacother. 2002 Feb;36(2):331-3. doi: 10.1345/aph.1A035. PMID: 11847957.
2. Krenzelok EP, Royal MA. Confusion: acetaminophen dosing changes based on NO evidence in adults. Drugs R D. 2012 Jun 1;12(2):45-8. doi: 10.2165/11633010-000000000-00000. PMID: 22530736; PMCID: PMC3585765.
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