Colchicine for constipation

Q: Colchicine tends to cause, - select either A or B

A) Constipation

B) Diarrhea

Answer: B

This question aims to bring to attention a little-known fact about colchicine. Constipation is a well-known issue in ICUs. Colchicine is effective in relieving ϲοոѕtipаtiоո, especially in patients who have this issue chronically. Their symptoms tend to get worse in the hospital. A dose of 0.6 three times a day to 1 mg per day is recommended.

Сοlϲhicinе should be avoided in patients with renal insufficiency. It may also cause myopathy.

#pharmacology

#GI

References:

 

1. Wald A. Slow Transit Constipation. Curr Treat Options Gastroenterol 2002; 5:279.

 

2. Taghavi SA, Shabani S, Mehramiri A, Eshraghian A, Kazemi SM, Moeini M, Hosseini-Asl SM, Saberifiroozi M, Alizade-Naeeni M, Mostaghni AA. Colchicine is effective for short-term treatment of slow transit constipation: a double-blind, placebo-controlled clinical trial. Int J Colorectal Dis. 2010 Mar;25(3):389-94. doi: 10.1007/s00384-009-0794-z. Epub 2009 Aug 25. PMID: 19705134.