Anbx with neuromuscular blockade

Q: Which of the following antibiotics has a neuromuscular-blocking property? - select one

A) Ampicillin

B) Bactrim (trimethoprim-sulfamethoxazole)

C) Clindamycin

D) Doxycycline

E) Erythromycin

Answer: C

Clindamycin has neuromuscular-blocking properties and enhances the effects of neuromuscular blocking agents. At higher doses, it can independently cause neuromuscular blockade.

Clinical significance: It should be used cautiously in patients receiving neuromuscular-blocking agents.

#pharmacology

References:

1. al Ahdal O, Bevan DR. Clindamycin-induced neuromuscular blockade. Can J Anaesth. 1995 Jul;42(7):614-7. doi: 10.1007/BF03011880. PMID: 7553999.

2. Best JA, Marashi AH, Pollan LD. Neuromuscular blockade after clindamycin administration: a case report. J Oral Maxillofac Surg. 1999 May;57(5):600-3. doi: 10.1016/s0278-2391(99)90083-6. PMID: 10319836.

3. Becker LD, Miller RD. Clindamycin enhances a nondepolarizing neuromuscular blockade. Anesthesiology. 1976 Jul;45(1):84-7. doi: 10.1097/00000542-197607000-00015. PMID: 937756.