Cefiderocol

Q: Cefiderocol belongs to which generation of cephalosporins? - select one

A) First generation 

B) Second generation 

C) Third generation

D) Fourth generation 

E) Fifth generation 

F) None of the above

Answer: F

Cefiderocol is unique because it does not belong to any of the generations of cephalosporins. It is a novel siderophore cephalosporin. It is active against multidrug-resistant (MDR) gram-negative bacteria, including ESBL- or carbapenemase-producing organisms and (MDR) P. aeruginosa, A. baumannii, Stenotrophomonas maltophilia, and Burkholderia cepacia. 

#pharmacology

References:

1. Parsels KA, Mastro KA, Steele JM, Thomas SJ, Kufel WD. Cefiderocol: a novel siderophore cephalosporin for multidrug-resistant Gram-negative bacterial infections. J Antimicrob Chemother. 2021 May 12;76(6):1379-1391. doi: 10.1093/jac/dkab015. PMID: 33532823.

2. Wu JY, Srinivas P, Pogue JM. Cefiderocol: A Novel Agent for the Management of Multidrug-Resistant Gram-Negative Organisms. Infect Dis Ther. 2020 Mar;9(1):17-40. doi: 10.1007/s40121-020-00286-6. Epub 2020 Feb 18. PMID: 32072491; PMCID: PMC7054475.