Sildenafil with inhaled NO

Q: What is the advantage of adding Sildenafil with inhaled NO (iNO) in the treatment of pulmonary hypertension?

Answer: Sildenafil not only decreases the pulmonary pressures but also prevents rebound pulmonary vasoconstriction on withdrawal of inhaled NO.

#pulmonary

#pharmacology

References:

1. Namachivayam P, Theilen U, Butt WW, Cooper SM, Penny DJ, Shekerdemian LS. Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children. Am J Respir Crit Care Med. 2006 Nov 1;174(9):1042-7. doi: 10.1164/rccm.200605-694OC. Epub 2006 Aug 17. PMID: 16917115.

2. Raja SG. Treatment of rebound pulmonary hypertension: why not sildenafil? Anesthesiology. 2004 Dec;101(6):1480; author reply 1481. doi: 10.1097/00000542-200412000-00039. PMID: 15564966.

3. Mehta S. Sildenafil for pulmonary arterial hypertension: exciting, but protection required. Chest. 2003 Apr; 123(4): 989-92