Chloride level in sepsis

Q: Which of the following is a prognostic marker of an increase in all-cause hospital mortality in sepsis? - Select one

A) Hyperchloremia 

B) Hypochloremia 

Answer: A

Some clinical and laboratory findings have been identified as markers of mortality in Sepsis. The prominent ones are:

1. Failure to develop a fever or having hypothermia with a temperature below 35.5ºC

2. Leukopenia with a white blood cell count (WBC) less than 4000/mm3, instead of leucocytosis

3. Thrombocytopenia with platelet count <100,000/mm3 

4. Hyperchloremia (Cl ≥110 mEq/L) at 72 hours after ICU admission

                                                     

#sepsis

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References:

                                                     

1. Peres Bota D, Lopes Ferreira F, Mélot C, Vincent JL. Body temperature alterations in the critically ill. Intensive Care Med 2004; 30:811.

2. Neyra JA, Canepa-Escaro F, Li X, et al. Association of Hyperchloremia With Hospital Mortality in Critically Ill Septic Patients. Crit Care Med 2015; 43:1938.

3. Thiery-Antier N, Binquet C, Vinault S, et al. Is Thrombocytopenia an Early Prognostic Marker in Septic Shock? Crit Care Med 2016; 44:764.